منابع مشابه
The alveolar macrophage.
The pulmonary macrophagic system is critical to the defense of the lung, keeping the alveoli clean and sterile and responding on demand with an adaptive outpouring of new cells into the air sacs. Under basal conditions alveolar macrophages, in common with other mononuclear phagocytes, are derived from the bone marrow. A population of macrophage precursors within the pulmonary interstitium provi...
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A mononuclear cell alveolitis, comprised in part of activated macrophages, is thought to precede granuloma formation and fibrosis in pulmonary sarcoidosis. Tumor necrosis factor-a (TNF), interleukin 1-f3 (IL-l), and prostaglandin E, (PGE,) are potent mediators released by activated alveolar macrophages. To determine if alveolar macrophage TNF, IL-1, and PGE, release was associated with clinical...
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PPARs, most notably PPAR-gamma, play a crucial role in regulating the activation of alveolar macrophages, which in turn occupy a pivotal place in the immune response to pathogens and particulates drawn in with inspired air. In this review, we describe the dual role of the alveolar macrophage as both a first-line defender through its phagocytotic activity and a regulator of the immune response. ...
متن کاملContra-lateral shoulder dislocation caused by seat belts in drivers and front-seat passengers
S reduce mortality of road traffic collisions mainly by reducing the severity of head injuries.1,2 Nevertheless, they can cause specific intra-abdominal and vertebral injuries.2 We found one report in the literature addressing the relationship between anterior dislocation of the restrained shoulder and seatbelts.3 We recently treated a restrained driver and a restrained front-seat passenger who...
متن کاملHuman Alveolar Macrophage Proteolytic
The occurrence of emphysema in people deficient in alphai-antltrypsin and the production of emphysema in experimental animals with elastolytic enzymes suggest proteolysis as a mechanism for the development of emphysema. To investigate the possible role of pulmonary alveolar macrophages in the pathogenesis of emphysema, we measured elastase, acid protease, and elastaselike esterase activities in...
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ژورنال
عنوان ژورنال: Immunity
سال: 2006
ISSN: 1074-7613
DOI: 10.1016/j.immuni.2006.03.008